South Florida Museum, [2]. Where Snooty the Manatee lives.
De Soto National Memorial, [3]. Features live reenactments of Conquistadors shooting things.
Arrive by air at Sarasota/Bradenton International airport in Sarasota. You can also fly into Tampa International airport in Tampa. Tickets to Tampa are generally cheaper and it's easier to get a direct flight since the airport is bigger.
Easy access by car from Interstate 75.
Anna Maria Island provides a free trolley service that runs the length of the island.
The MCAT (Manatee County Area Transit) bus system stops at all the major shopping areas, beaches, schools, hospitals, etc.