From Yangon, leave in the morning by taxi (US$40-50), or by bus (from the corner of Strand and Sule Pagoda Road and also from the Aung Mingalar Bus Terminal), or by train (US$4 each way, US$2 for ordinary seat, all Mandalay and Mawlamyine bound trains stop there). A taxi is the best because you'll need one to see the sights in Bago (which are quite far apart) and you can stop at Taukkyan on the way.