From Buenos Aires (Retiro) there are plenty of bus companies that will take you there. Some of them are FlechaBus, Basa and Pulqui. The trip is 6 hours long or a bit less, so many people travel by night. The last bus in the night leaves from Buenos Aires at 0:30, or from Santa Fe to Buenos Aires at 1:50 AM. Some of the services include meals, most of them have very comfortable seats.

On Santa Fe's bus terminal (4 streets from center town) you will find many bars and fast food restaurants. There are personal pay-per-view television screens and free WiFi service.

Santa Fe's airport is in the near location of Sauce Viejo and its international code is SAAV (local code SFN).

Aerolíneas Argentinas flies daily (except Saturday), with a trip time of 50 minutes, departing from Buenos Aires domestic airport (Aeroparque). It is said the new airline named "SOL" will have two or three daily services starting August 2006.